Sermorelin & Ipamorelin

Nothing can be accomplished in the human body without a signal.

This signal can come in many forms, but it is often a hormone of some kind.

Our powerful hormones can be created from various kinds of molecules and they possess the ability to stop, start, enhance, or restrict the actions of various glands, tissues, organs, and systems across the body. Imagine that we were able harness this power to do the same thing – control processes throughout the body at will by introducing the signal(s) that we need.

Well, we live in an amazing time, because one of the more recent breakthroughs in the fields of biological signalling and anti-aging involves the harnessing of peptides to do just that. Therapeutic peptides (short chains of amino acids/fragments of proteins) originate from molecules that already occur naturally within the body, but we are now able to build and utilize them for a variety of purposes. Research and anecdotal reports are proving that certain peptides can effectively slow down the aging process, increase muscle mass, decrease body fat, reduce inflammation, heal the gut, and likely countless other potential applications still waiting to be discovered.

Two specific peptides that are brilliant examples of what modern medicine is able to do in order to slow down the aging process are sermorelin acetate (a.k.a sermorelin) and ipamorelin. These signaling molecules mimic two separate endogenous hormones, enabling them to stimulate the release of growth hormone naturally from the pituitary gland – and they are able to do so in a way that is safe, unique, and complementary with one another. This synergistic effect is exactly why practitioners and patients are experiencing incredible results by combining sermorelin and ipamorelin. This dynamic duo’s ability to work together will be the focus of this article but we will also cover how they differ from one another, the potential side effects of each, and who to trust with your peptide protocols in order to ensure that you are getting the highest quality products and services available.

Peptides have quickly positioned themselves at the forefront of individualized medicine and they may have the ability to drastically improve your health and quality of life. How peptides work in the body may seem like something out of a science fiction novel, but the research, mechanisms, and real world experiences of people all over the world are proving them to be anything but fiction. 

What Are Peptides?

It’s probably best we start with breaking down some more of the mystery that surrounds peptides. In this context, peptides are essentially just signalling molecules that have been derived from, or are compounds already found within the body.

Sermorelin and ipamorelin are both categorized as growth hormone secretagogues. Secretagogues are nothing more than something that promotes the secretion/release of a chemical messenger such as a hormone. In this case, they promote the production and secretion of growth hormone from the amazing little hormone factory in your brain called the pituitary gland. What is most interesting is that they are able to accomplish this task in vastly different, yet complementary ways. 

Sermorelin Mechanism of Action

Sermorelin stimulates the production and release of growth hormone in a relatively straightforward way – by mimicking growth hormone releasing hormone (GHRH).

You don’t need to know much about the endocrine system or peptides in order to successfully guess what GHRH does – it causes the release of growth hormone. GHRH is typically released from another location within your brain and then it travels to the pituitary gland where it is interpreted and acted upon. When GHRH is administered in the form of sermorelin however, the peptide flows through your entire circulation – binding to GHRH receptors in areas all over the body, but especially on the pituitary gland. Another important aspect of using sermorelin to stimulate growth hormone release is that it allows the body’s natural feedback (shutoff) mechanisms to function properly. Once sermorelin has stimulated a certain amount of growth hormone to be released, another hormone known as somatostatin kicks in, effectively shutting down the growth hormone release. Like we said, the mechanism by which sermorelin works in the body is pretty straightforward – ipamorelin on the other hand, will take a bit more explanation. 

Ipamorelin Mechanism of Action

Ipamorelin acts in an entirely unique way to stimulate growth hormone release. To fully understand it, we will need to quickly cover an entirely new hormone that we have yet to discuss named ghrelin.

Ipamorelin is able to mimic ghrelin in exactly the same way sermorelin is able to mimic GHRH. Although ghrelin doesn’t get as much attention as some of the A-list hormones like insulin, growth hormone, testosterone, and estrogen, it absolutely should be a household name due to its importance within the body. Only discovered in 1999, ghrelin has profound regulatory effects on your metabolism including increasing or decreasing hunger, inhibiting stored fat breakdown, and perhaps most importantly for this article, the release of growth hormone from the pituitary gland. Ghrelin is one of only three hormones which have the ability to regulate growth hormone release from the pituitary gland. First is GHRH (sermorelin or similar molecule), then there is somatostatin (which stops the release of growth hormone), and last but not least is ghrelin. Ghrelin is able to act upon the pituitary gland in this way because growth hormone is partially responsible for initiating the breakdown of stored body fat for use as energy, as well as preventing the breakdown of muscle tissue – among many other roles. 

Now that you have an idea of how ghrelin is able to influence growth hormone release, understanding how a peptide that functionally mimics ghrelin is able to initiate the release of growth hormone should be a pretty easy leap. Ipamorelin binds to ghrelin receptors on the pituitary gland, switching them on in the same way that ghrelin naturally would. These on-switches are completely separate from the ones that sermorelin activates, enabling them to work synergistically to accomplish the same task. Most importantly, they are able to do so with no effect on the rest of your body’s hormones. There is always one major factor which must be evaluated whenever you are considering any kind of anti-aging treatment however – whether the benefits outweigh the potential side-effects. Fortunately, in the case of utilizing sermorelin and ipamorelin, that choice seems to be pretty easy to make.

Side Effects of Sermorelin and Ipamorelin

Neither sermorelin or ipamorelin have many side effects that are likely to send anyone to seek help elsewhere in the fight against the aging process.

In fact, ipamorelin specifically is largely considered to be one of the safest and most effective peptide treatments available. Sermorelin has been known to cause mild side-effects for some people such as flushing, headaches, nausea, dizziness, and redness or swelling around the injection site. Ipamorelin’s possible side effects mirror that of sermorelin with headaches and nausea topping the list of adverse events reported from using the impressively safe peptide.

Both are typically safe and side-effect free when used in the doses prescribed by a qualified medical practitioner. Knowing what that dosage should be is yet another reason why it is important to purchase your peptides from a reputable source. Unsurprisingly, there really is no shortage of websites selling inferior anti-aging products containing little or no actual peptides or other beneficial compounds. That being said, starting a peptide protocol can be done online safely and easily with a bit of education first. 

Buy Sermorelin & Ipamorelin Online

Finding a reliable business you can trust comes down to a few things.

First, look for a website that requires you to speak to a medical professional to obtain your prescription. In order to buy ipamorelin or sermorelin online, you are required to have a prescription just like you would at any pharmacy. There are businesses that offer telehealth services like Ikon Health that are able to walk you through this entire process from the convenience of your smartphone. If the company doesn’t require a prescription, find one that does!

Second, look for a company that has a solid track record with customer feedback to back it up. If they are a reliable company, they will no doubt have testimonials from patients that have worked with them. Buying peptides online may have been a questionable endeavor in the past, but luckily the industry has evolved and there are now many companies that provide excellent service, products, and results. 

Should You Try Sermorelin & Ipamorelin?

Ipamorelin and sermorelin are just two of the many peptides that have earned an excellent record of safety and effectiveness. Those individuals who are looking for the physiological and psychological benefits of naturally increasing growth hormone should look no further than these two peptide treatments. If you are searching for more energy, an improved body composition, and to generally fight the aging process, a protocol combining these two potent growth hormone secretagogues is an excellent choice. Visit our website today or come into our location to speak with one of our staff to buy CJC-1295 or purchase Ipamorelin. Unlike most wellness clinics, at Ikon Health we know that tools like peptides, injections, and IV therapy are but only part of the big picture – making lasting changes will take time and effort!


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